![]() We used a study code name of Curcumin PotentiaLApplicability and Rationale for Chemotherapy-Induced Cognitive Impariment Treatment EfficacY (abbreviated as CLARITY trial). This was a randomized, double-blind, placebo-controlled trial involving cervical cancer patients who underwent chemotherapy regimen of carboplatin-paclitaxel. Therefore, in this study, we would like to evaluate the safety profile of curcumin and if curcumin administration can maintain cognitive function and prevent CICI administration among cancer patients receiving chemotherapy. Protective effect and safety profiles of curcumin against central nervous system, particularly among subjects receiving chemotherapy, has never been studied before. Curcumin is also known to increase the effectiveness of chemotherapeutic agents via increasing cancer cells sensitization against chemotherapy and protecting normal cells from chemotherapy damage (Tan and Norhaizan 2019). Curcumin is a safe natural product to be consumed by humans (Abd El-Hack et al. ![]() Recently, there has been multiple pharmacological studies done to investigate the antioxidant, antiinflamation, anticarcinogenic, and anti-bacterial effects of curcumin. It is used to treat vomiting, headache, diarrhea, and other diseases (Panahi et al. Curcumin has been widely used as a staining agent and taste compliment in food industry, as well as being used as a herbal medicine in Asian countries for centuries. Despite its magnitude, there are several reasons why CICI cannot be properly diagnosed and receive an appropriate treatment, mainly due to (1) reversible nature, despite in several studies, it was reported that cognitive function deficit can persist in the long term, (2) CICI symptoms are often minimal, thus the use of standard screening test for cognitive impairment such as MMSE may not be able to detect CICI accurately, (3) unstandardized CICI evaluation and diagnosis confirmation, (4) variations in the process of diagnostic approach, (5) there has not been any treatment to prevent CICI or to maintain cognitive function among cancer patients who receive chemotherapy.Ĭurcumin (C21H20O6) is an active substance of natural herbs Curcuma xanthorriza roxb. CICI has a relatively high prevalence among cancer patients who receive chemotherapy. Several chemotherapeutic agents administered either as monotherapy or in combination may induce long term adverse effects against cognitive function, thus reducing their overall quality of life (Mounier et al. Administration of curcumin extract with intermittent dose escalation regimen proved to be safe and able to improve cognitive function of CICI patients clinically and statistically significant.Ĭhemotherapy-induced cognitive impairment (CICI) is neurocognitive disorder in the aspect of memory, learning, concentration, reasoning, executive function, attention, and visuospatial during and after chemotherapy administration (Ren et al. 0.04) versus placebo in between-group and between-subject analyses, respectively. The group of subjects receiving curcumin extract experienced clinically and statistically significant improvements in cognitive function based on the Stroop test (∆ median 8.57 vs. The percentage of drop-out, mortality, and adverse drug response were relatively comparable between each treatment arm. A total of 78 subjects were equally divided into the treatment and control groups. Cognitive function was evaluated pre- and post-therapy using the AFI questionnaire, Stroop test, and MoCA-Ina. Subjects divided into two groups that received curcumin and placebo caplets by dose escalation method from 240 to 400 mg intermittently (14 days on and 7 days off) between chemotherapy cycles. This study was a double-blind randomized controlled trial clinical trial in patients with cervical carcinoma who underwent a carboplatin-paclitaxel chemotherapy regimen from March to October 2021 at single center hospital. To evaluate the safety and effectiveness of curcumin extract to improve cognitive function in CICI patients. No proven safe and effective therapeutic regimen are available to improve cognitive function in CICI patients. Chemotherapy-induced cognitive impairment (CICI) is an impairment of memory, learning power, concentration, reasoning, executive function, attention, and visuospatial during and after chemotherapy exposures.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |